University of California
Hammock Laboratory of Pesticide Biotechnology
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Shirley Gee (752-8465)
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Research Project: Development and application of antibody-based methods for the detection of small molecules. Antibody production, assay development, validation, immunoaffinity chromatography, interfacing immunoassays with classical sample preparation schemes. Development of novel antibody-based methods such as with the accelerator mass spectrometer and near-infrared dyes as labels. Application of immunoassays to exposure assessment. Administrative: General laboratory management, safety, chemical & equipment inventory, grant & manuscript writing and laboratory personnel training and supervision. |
Sung Hee Hwang (754-8884)
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Research Project: 1) Synthesis and biological evaluation of dual inhibitors for cyclooxygenase-2 and soluble epoxide hydrolase using structure-based design and modern medicinal chemistry tools. 2) Design and synthesis of inhibitors for human soluble epoxide hydrolase by parallel and combinatorial synthesis for the lead optimization based on SAR study, physical property determination and PK analysis. 3) Development of novel fluorescent assay reagents for rapid and precise measurement of environmental contaminants by labeling them with two fluorophores called “molecular tripod”. |
Ahmet 'Bora' Inceoglu (752-6571)
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Research Project: Assessment of the role of sEH in nervous system. Investigate the effects of inhibiting sEH in animal models of pain. |
George Kamita (754-8884)
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Research Project: 1) Insect Physiology: Fundamental and applied studies of the role of juvenile hormone-specific esterase and epoxide hydrolase in insect development. 2) Insect Virology: Genetically modified baculoviruses and small RNA viruses for pest insect control. 3) Insect Biotechnology: Mechanisms of RNA interference in hemipteran insects |
Hee Joo Kim (754-8884)
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Research Project: Development of immunoassays for pyrethroid metabolites. Development of novel immunoassay formats using phage peptide display. |
Junyan Liu (752-5109)
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Research Project: Discovery and development of drugs from natural library and synthetic bank; Pharmacological study of selective modulation of metabolism of arachidonic acid; Pharmacokinetics and metabolomics. |
Christophe Morisseau (752-6571)
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Research Project: Study the role of esterases and epoxide hydrolases in biology and xenobiotics metabolism. Toward this purpose, study their mechanism of action, develop specific inhibitors and design fluorescent reporter assay; as well as studying the kinetic of hydrolysis of natural substrates. All of these mainly in mammals; but also in other organism such as chicken or bacteria. Study also the role of the phosphatase activity of sEH. |
Jun Yang (752-5109)
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Research Project: 1) Role of soluble epoxide hydrolase in lung diseases including asthma and Chronic Obstructive Pulmonary Disease. 2) Metabolomics method development and applications including the profiling of the oxylipins such as eicosanoids. 3) Qualification and Quantification of small molecules using chromatography and mass spectrometry. 4) Identification of proteins by chromatography and mass spectrometry. |